coiaward2010

EUREKA = ELN registry

Study title

EUREKA = ELN registry for patients with chronic myeloid leukemia (CML) in chronic phase (CP) who have been treated with tyrosine kinase inhibitors for at least two years

Scientific title

European survey on the assessment of deep molecular response in chronic phase CML patients after at least two years of therapy with tyrosine kinase inhibitors (EUREKA)

Indication and most important inclusion criteria

This European registry enrolls male or female patients from 18 years of age with a diagnosis of BCR-ABL positive CML in chronic phase (CP).
The registry will be available to all CML patients after at least two years of treatment with one or more tyrosine kinase inhibitor(s) (TKIs) at any prescribed dose as per routine clinical practice for a minimum of 24 months at registry entry.

Short description of intervention

The EUREKA registry will collect and evaluate medical data and molecular results of the assessment of residual disease (deep molecular response, MR4.5) in patients with chronic myeloid leukemia (CML) in chronic phase (CP).

Deep molecular response is assessed routinely in the course of treatment of CML. Additional blood sampling will not be required.

Assessment results and biomaterials will be collected, stored and evaluated by specialized laboratories (certified MR4.5 labs). The data analysis is aiming to show the availability of deep molecular response assessment for all CML patients in Europe.

Type of study

Other trial = epidemiological registry

Current status

Recruiting

Study sponsor

European LeukemiaNet (ELN)

Scientific lead / contact

...

Principal investigator

Prof. Dr. med. Andreas Hochhaus
Universitätsklinikum Jena
Klinik Innere Medizin II
07740 Jena
Germany

Additional information

Description available at European Treatment and Outcome Study

Study centers / principal investigators

Participating countries:

Austria

Belgium

Bosnia-Herzegovina

Bulgaria

Croatia

Czech Republic

Denmark

France

Germany

Greece

Ireland

Italy

Lithuania

Norway

Poland

Portugal

Rumania

Slovenia

Spain

Switzerland

United Kingdom