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CML Clinical Trials

CML Clinical Trials Database -

Cancer research is an area where new treatments are being explored for the prevention, diagnosis and treatment of different types of cancer. Researchers conduct so called "clinical studies" or "clinical trials" to improve treatment options for the patients of today and tomorrow. These studies are performed to investigate the biological mechanisms of the disease, to optimize the use of existing therapies or to test new forms of treatment or new drugs to find out whether they are more effective or better tolerated. For more information please read our manual "what are clinical trials?"

Patients wishing to participate in clinical studies often look for a central source of information where they can find easy-to-understand facts on ongoing trials. CML Advocates Network is now hosting an inofficial database of current CML trials which have been initiated by academia (universities) or by pharmaceutical companies. This database is run by patients for patients and is set up as a dynamic register in which data are updated on an ongoing basis. CML Advocates Network has taken utmost care to verify the data entered, however, cannot assume any liability for the accuracy or completeness of the information. Patients should consult their doctor for personal advice and/or their scientific contact/study staff for the most up-to-date study information.

Do you know of any study that is not yet listed here? Please let us know by filling out this form. Or is there an entry which should be corrected? If so, please send us an email. Please also visit our forum if you have any questions or wish to share your experience on these studies.

CML Clinical Trials Database

1. First line trials

1 DasaHIT = Dasatinib Holiday for Improved Tolerability [Germany]
Updated: 30 August 2017

4. Treatment of advanced phases

1 CA180-357 = Decitabine + Dasatinib for Blast Phase CML
Updated: 20 March 2015

5. Treatment discontinuation trials

1 LAST Stopping Tyrosine kinase inhibitors
Updated: 11 December 2015
2 MSIT = Malaysia Stop Tyrosine Kinase Inhibitor Trial
Updated: 11 December 2015
3 ENESTPath Patient's Voice Italian Substudy [Italy]
Updated: 15 February 2016
4 PIO2STOP = Pioglitazone plus TKI to prepare for second stopping attempt [France]
Updated: 16 August 2017

9. Trials that are no longer recruiting

1 DASPERSE = Dasatinib in chronic phase myeloid leukemia patients with chronic toxicity to imatinib
Updated: 7 July 2015
2 DASFREE (CA180-406) = Discontinuation of dasatinib in CP-CML patients with stable MR4.5
Updated: 21 June 2016
3 ENESTop = A clinical research study evaluating the possibility to stop the drug nilotinib in chronic myeloid leukemia (CML) patients who have very small amount of leukemia cells remaining after nilotinib treatment
Updated: 13 March 2015
4 ENESTFreedom = Nilotinib Treatment-free Remission Study in CML (Chronic Myeloid Leukemia) Patients
Updated: 27 January 2017
5 CAMN107A2203 = Study of the Efficacy and Safety of Oral Nilotinib in CML in Children and Adolescents
Updated: 31 January 2017
6 BFORE (AV001) = Bosutinib versus Imatinib in Adult Patients with Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia
Updated: 25 September 2017
7 SPIRIT2 = Comparison of imatinib versus dasatinib in patients with newly-diagnosed chronic phase chronic myeloid leukaemia Scientific title
Updated: 22 January 2015
8 SIMPLICITY (CA180-330)
Updated: 7 July 2015
9 TIGER (CML V) = Nilotinib or nilotinib + peginterferon with the aim to discontinue treatment
Updated: 30 August 2017
10 CHOICES = Imatinib Mesylate With or Without Hydroxychloroquine in Treating Patients With Chronic Myeloid Leukemia
Updated: 14 April 2015
11 EUROSKI (EUROStopKinaseInhibitor)
Updated: 2 December 2014
12 ENESTPath = A Study to Assess the Effect of a Longer Duration of Consolidation Treatment With Nilotinib on TFR in CP CML
Updated: 6 July 2015
13 BYOND (B1871039) = Safety and Efficacy of Bosutinib in Ph+ CML Previously Treated with TKI
Updated: 1 September 2017

8. Other haematological trials (not CML)

1 DACOTA = Decitabine with or without Hydroxyurea versus Hydroxyurea in CMML[Europe]
Updated: 4 November 2015